Research Explorer

Project

Role of monocytic cells in the pathogenesis of nephropathogenic infectious bronchitis virus (IBV) in chickens
Code
01DI3415
Duration
01 September 2015 → 15 May 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
Keywords
respiratory pathogenesis IBV Infectious bronchitis virus nephropathogenic monocytic cells
 
Project description

We have recently found that respiratory and nephropathogenic IBVs show similar replication kinetics in respiratory mucosa explants whereas they replicate differently in monocytic cells: nephropathogenic IBV causes a sustainable replication whereas respiratory IBV does not. Now, we want to find out if this in vitro finding may explain why nephropathogenic IBV spreads to the kidneys.