Research Explorer

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Project

Retracing the steps of enzyme evolution: an exploration of ancestral sequence space

Outputs and Outcomes

Publications

Evolution of phosphorylase activity in an ancestral glycosyltransferase

Jorick FranceusJose Pablo Rivas-FernandezJolien LormansCarme RoviraTom Desmet

A1 Journal Article in ACS CATALYSIS

High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase

Jorick FranceusManon SteynenYentl AllaertKato BredaelMatthias D'hoogheTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Insertions and deletions in protein evolution and engineering

Simone SavinoTom DesmetJorick Franceus

A1 Journal Article in BIOTECHNOLOGY ADVANCES

Building mutational bridges between carbohydrate-active enzymes

Jorick FranceusJolien LormansTom Desmet

A1 Journal Article in CURRENT OPINION IN BIOTECHNOLOGY

Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3

Jorick FranceusJolien LormansLore CoolsMatthias D'hoogheTom Desmet

A1 Journal Article in ACS CATALYSIS