Moral science as a relatively unique discipline can be roughly situated in the broad domain of ethics, and more specifically as a particular way of confronting the integration of ‘what is’ and ‘what ought to be’. While neighboring to (more or less) recent developments like ‘empirical ethics’, the ‘moral scientific’ approach uncovers fundamental methodological and philosophical questions that are relevant and timely for value theory (‘axiology’) in general. Three axes of such questions concern (i) the feasibility of demarcating moral from non-moral value, (ii) speculation as a normative activity to emancipate from what ‘is’ to what ‘ought to be’, and (iii) the (paradoxical) trade-off between contextualization and systematization. This project aims to study these three axes from the distinct moral scientific point of view, merging theoretical ethics with case-studies from practical ethics.