Code
3F020510
Duration
01 October 2010 → 30 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Natural sciences
- Microbiology
- Systems biology
-
Medical and health sciences
- Laboratory medicine
- Microbiology
- Laboratory medicine
- Laboratory medicine
- Microbiology
Keywords
Staphylococcus aureus
AIP antagonist
abscess formation
AIP agonist
accessory gene regulator
nasal colonisation
rabbit
Project description
The accessory gene regulator (agr) is a major virulence regulator of Staphylococcus aureus, modulating bacterial virulence factor expression by secretion of auto-inducing peptides (AIPs). In in vitro models and subsequent in vivo rabbit models, the influence of agr expression in S. aureus on nasal colonisation and abscess formation will be evaluated, using an AIP agonist and antagonist.