The successfully adoption and scale up of Orange Fleshed Sweet Potato (OFSP) as a food-based intervention is limited, more so in Ugandan refugee settlements and host communities. OFSP is rich in vitamin A and is cost-effective in humanitarian settings, however OFSP viruses are very prevalent andlimit productivity. This project supports the establishment of a community-focused and certified research centreof excellence in tissue culture micropropagation/multiplication, to supplyvirus-free high-performing OFSP cultivars. Using a Research-to-Action approach, existing farmer adoption andconsumer preferences for OFSP will be established, with a comprehensive analysis of the operations of existing OFSP vines input suppliers. This will inform the development and optimisation of in vitro tissue culturetechniques for efficient elimination of OFSP viruses and eventual scaling of the production of virus-free OFSPcultivars for sustainable adoption and consumption in refugee settlements and host communities in western andnorthern Uganda.