The project aims to mitigate enteric methane in Vietnamese dairy goats, utilising local feed resources to address climate change, while focusing on local resources and goats to enhance relevance to smallholders. To broaden anti-methanogenic strategies, in vitro configurations are optimised via in vitro–in vivo data, allowing subsequent screening and testing through a state-of-the-art in vitro-in vivo approach supported by metagenomic research to understand the mode of action.