Research Explorer

Project

Investigation of anti-cancer activities of solanoceae -specific withanolides in myeloma
Code
01W02209
Duration
08 February 2010 → 07 February 2014
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Hematology
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Hematology
    • Laboratory medicine
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
Keywords
withanolide solanoceae myeloma
 
Project description
 

Solanoceae plants have been used for centuries in ancient medicine to treat inflammation and cancer. We have identified various steroidal withanolides in leaf which have potent anti-cancer activities. In the proposed study, we would like to investigate whether 1) withanolides specifically kill MM cells, but not normal blood cells, from patients with MM and 2) withanolides can inhibit disease progression in a MM mouse model.