Project

Identification and functional analysis of novel organ-specific target genes of the canonical Wnt pathway, using transgenic fluorescent techniques in Xenopus

Duration
01 January 2008 → 30 December 2012
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
oncogenes cancer development
 
Project description

We want to identify novel target genes of the canonical Wnt pathway, which is often aberrantly activated in human cancer. These genes will be identified in different organs of transgenic tadpoles (Xenopus) in which the Wnt pathway is genetically manipulated. To functionally characterize these genes we will perform overexpression and knock-down experimemnts in tadpoles expressing different fluorescent reporter genes. For this we will use a fluorescent steromicroscope with a time lapse module.