Research Explorer

Project

Nanobody-assisted manipulation of the tumor suppressor p53.
Code
178GE0111
Duration
01 October 2010 → 05 January 2016
Funding
Regional and community funding: IWT/VLAIO
Research disciplines
  • Medical and health sciences
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
  • Engineering and technology
    • Catalysis and reacting systems engineering
    • Chemical product design and formulation
    • General chemical and biochemical engineering
    • Process engineering
    • Separation and membrane technologies
    • Transport phenomena
    • Other (bio)chemical engineering
Keywords
nanobody p53 tumor suppressor
 
Project description
 

The tumor suppressor and transcription factor p53 plays a key role in cell cycle regulation, apoptosis and senescence and is frequently inactivated in human tumors. Nanobodies against p53 are generated and characterized, in vitro and in vivo. These nanobodies are subsequently utilized to manipulate the activity of p53 in cells in terms of intracellular localization and activity.