Research Explorer

Project

Generation of autologous T cells against acute myeloid leukemia by transduction of hematopoietic stem cells with T cell receptor genes and subsequent differentiation to T cells
Code
365J2309
Duration
01 January 2009 → 31 December 2012
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Hematology
    • Immunology
    • Laboratory medicine
    • Hematology
    • Immunology
    • Laboratory medicine
Keywords
cell therapy stem cells T cells
 
Project description

Hematopoietic stem cells will be transduced to express a T Cell Receptor. This receptor will be optained by immunizing against WT1 tumor antigen. The T cell receptor genes will be cloned from WT1 speciific T cells and subsequently used for transduction of the stem cells. Stem cells will be differentiated in vitro to T cells and functionality will be assayed in an in vivo animal model