Project

Disease-modifying characteristics of LXR-dependent signaling pathways in infectious and non-infectious inflammatory lung diseases

Duration
01 January 2009 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Respiratory medicine
    • Immunology
    • Microbiology
    • Respiratory medicine
    • Immunology
    • Respiratory medicine
Keywords
liver X receptor lung inflammatory disease cholesterol metabolism Tuberculosis (TB) asthma
 
Project description

This study aims to unravel the molecular basis by which LXR-dependent pathways contribute to pulmonary inflammation triggered by infectious and non-infectious agents. The disease-modifying potential of LXR-dependent pathways will be investigate using LXR knockout mice and synthetic LXR agonists. Success will aid in the identification of elevant key mediators and novel inflammatory disease-related pathways, essential in triggering lung diseases