Code
3G006309
Duration
01 January 2009 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Medical and health sciences
- Immunology
- Respiratory medicine
- Immunology
- Microbiology
- Respiratory medicine
- Immunology
- Respiratory medicine
Keywords
liver X receptor
lung inflammatory disease
cholesterol metabolism
Tuberculosis (TB)
asthma
Project description
This study aims to unravel the molecular basis by which LXR-dependent pathways contribute to pulmonary inflammation triggered by infectious and non-infectious agents. The disease-modifying potential of LXR-dependent pathways will be investigate using LXR knockout mice and synthetic LXR agonists. Success will aid in the identification of elevant key mediators and novel inflammatory disease-related pathways, essential in triggering lung diseases