With this funding application we want to expand the analytical capacity of the ProGenTomics core facility with the robustness, ultra-high sensitivity, throughput and quantitative accuracy of a Waters Acquity UPLC system coupled to a Xevo TQ-XS triple quadrupole mass spectrometer. This refurbished, and therefore affordable system will allow for the simultaneous analysis of over 25 analytes per sample, with quantification limits reaching the low attomole range and a throughput of up to 700 samples per day. This will enable us to facilitate the growing analytical needs of our numerous (future) collaborators, supporting research projects that currently span a wide range of applications including pathogen detection, drug response profiling, clinical metabolomics, forensic protein analysis, allergen detection in food, and even sex determination of human remains in an archaeological context.