Global implementation of cancer screening can be hindered by differences in cultures and available resources between countries. The EU-funded CHILI project will address this challenge by determining the acceptability, feasibility and cost-effectiveness of the ELEVATE cervical cancer screening tool for women in low-income countries. This portable, battery-powered device comprises a human papillomavirus DNA test and a proteomic biomarkers detection sensor. Social scientists will investigate current screening practices and draw up a tailored strategy embedded in the current health system, while engineers will validate the self-testing device and adapt it for large-scale manufacturing at an affordable cost. Public health specialists and health economists will then evaluate the implementation of the screening tool to determine its suitability and cost-effectiveness.