General goal FUNCTIONARY aims to establish a set of guiding principles for functional safety (FS) in the chemical process industry following a novel, enriched, science-based approach. These guiding principles should lead to more reliable and lean FS measures and designs. Ideally, they already anticipate and account for a shift in the approach towards producing (base) chemicals: from monolithic plants, designed to produce for several decades, to modular and flexible solutions with many FS challenges. The set of guiding principles will be verified through generic industrial use cases, for which field data will be made available through the essenscia Process Safety Academy (EPSA) and its industrial members. Concrete goals and criteria: To achieve the general goal described above, and to tackle the major shortcomings of the current approach towards FS, the following concrete objectives and criteria are specified: Pillar I objective: To develop guidance for risk analysis to objectify risk reduction as input for FS. To do so, the following criteria are set:   o I.1: Enable risk analysis based on a science-based reactor model; o I.2: Reduce cost for risk analysis by 25%; o I.3: Develop a general safeguarding philosophy for the process industry; and o I.4: Reduce uncertainty on risk analysis by an order of magnitude of the risk matrix.   This objective and its criteria will be pursued within WP2.