Research Explorer

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Project

The role of NaV1.9 and GPR35 in inflammatory pain

Outputs and Outcomes

Code

01CD03724

Duration

01 November 2024 → 31 July 2025

Funding

Regional and community funding: Special Research Fund

Promotor

Frank Bosmans

Fellow

Margaux Theys

Research disciplines

Medical and health sciences
- Molecular biophysics
- Neurophysiology
- Electrophysiology

Keywords

G-protein coupled receptor 35 (GPR35) voltage-gated sodium ion channel NaV1.9 Pain

Project description

Behavioral assays on mice have indicated the implication of both NaV1.9 and GPR35 in inflammatory pain. However, how these proteins are affected by inflammation and their role in the ensuing hyperalgesia is currently unclear. This research aims to elucidate the impact of GPR35 signaling on NaV1.9 function through immunostainings, electrophysiological recordings and pain assays in mice.

English

Dutch

English

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