Code
01CD14423
Duration
05 March 2024 → 04 September 2024
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Stem cell biology
- Developmental neuroscience
Keywords
microcephaly
brain organoids
DNA damage
ionizing radiation
Project description
Exposure of pregnant women to ionizing radiation (IR) can profoundly impact the fetal brain development, leading to microcephaly. To date, the mechanisms of radiation-induced neurodevelopmental disorders remain insufficiently known. To fill this gap and to better resemble aspects of the human brain developmental physiology to study mechanisms of IR-induced microcephaly, here we use human brain organoids.