Research Explorer

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Project

Role of natural killer T cells in the pathophysiology and treatment of experimental arthritis

Outputs and Outcomes

Code

3F000408

Duration

01 October 2008 → 30 September 2012

Funding

Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)

Promotor

Dirk Elewaut

Fellow

Sandrine Aspeslagh

Research disciplines

Medical and health sciences
- Immunology
- Immunology
- Public health care
- Immunology

Keywords

autoimmunity cytokines NKT cells

Project description

Stimulation of invariant NKT (iNKT) cells has a positive influence in several autoimmune diseases (which are mainly characterised by th1 activation). Depending on the stimulation by different synthetic analogs of xGalCer (a known iNKT activator) the Th respons can be polarised to a Th1 versus Th2 respons. By this method we want to develop new therapeutic strategies for autoimmune diseases.

English

Dutch

English

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