Research Explorer

Project

The function of PHF6 in normal T-cell development and T-cell acute lymphoblastic leukemia
Code
3E013112
Duration
01 October 2012 → 30 September 2018
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
Keywords
leukemia PHF6 T-ALL T-cell tumor suppressor
 
Project description
 

T-ALL results from the malignant transformation of thymocytes and mainly affects children. Recently, PHF6 was identified as a novel tumor suppressor gene in T-ALL at the Center of Medical Genetics Ghent. The aim of this project is to investigate the role of PHF6 in the development of normal T-cells and T-ALL and to unravel transcriptional networks regulated by PHF6