Project

Network-based approaches for the identification and mode of action determination of anti-bacterial agents

Code

179J14013

Duration

01 January 2013 → 31 December 2016

Funding

Regional and community funding: various

Promotor

Kathleen Marchal

Research disciplines

Natural sciences
- Applied mathematics in specific fields
- Computer architecture and networks
- Distributed computing
- Information sciences
- Information systems
- Programming languages
- Scientific computing
- Theoretical computer science
- Visual computing
- Other information and computing sciences
- Bioinformatics and computational biology
- Microbiology
- Systems biology
Medical and health sciences
- Bioinformatics and computational biology
- Laboratory medicine
- Microbiology
- Bioinformatics and computational biology
- Laboratory medicine
- Public health care
- Public health services
- Bioinformatics and computational biology
- Laboratory medicine
- Microbiology
Engineering and technology
- Scientific computing

Keywords

drug development bacterial biofilm network-based dataintegration

Project description

Drug repurposing and the design of polypharmacological and drug-cocktailing strategies by combining in-house phenotypic and molecular data with advanced bioinformatics approaches. This implies 1) constructing drug-target networks,

2) constructing interaction networks from publicly available data, 3) determining the mode of action of drugs by interrogating interaction networks with in-house data, 4) testing the phenotypic and molecular effect of anti-biofilm agents.