Project

Network-based approaches for the identification and mode of action determination of anti-bacterial agents

Duration
01 January 2013 → 31 December 2016
Funding
Regional and community funding: various
Research disciplines
  • Natural sciences
    • Applied mathematics in specific fields
    • Computer architecture and networks
    • Distributed computing
    • Information sciences
    • Information systems
    • Programming languages
    • Scientific computing
    • Theoretical computer science
    • Visual computing
    • Other information and computing sciences
    • Bioinformatics and computational biology
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Bioinformatics and computational biology
    • Laboratory medicine
    • Microbiology
    • Bioinformatics and computational biology
    • Laboratory medicine
    • Public health care
    • Public health services
    • Bioinformatics and computational biology
    • Laboratory medicine
    • Microbiology
  • Engineering and technology
    • Scientific computing
Keywords
drug development bacterial biofilm network-based dataintegration
 
Project description

Drug repurposing and the design of polypharmacological and drug-cocktailing strategies by combining in-house phenotypic and molecular data with advanced bioinformatics approaches. This implies 1) constructing drug-target networks,

2) constructing interaction networks from publicly available data, 3) determining the mode of action of drugs by interrogating interaction networks with in-house data, 4) testing the phenotypic and molecular effect of anti-biofilm agents.