Project

Early event in the interaction of antigens/microorganisms with intestinal epithelial cells and intestinal dendritic cells: development of new oral delivery system

Duration
01 January 2010 → 17 May 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
  • Medical and health sciences
    • Immunology
    • Immunology
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Immunology
  • Engineering and technology
    • Process engineering
    • Polymeric materials
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
vaccination immunology mucosal
 
Project description

This project aims to study early events in the interaction of antigens/microorganisms with epithelial cells and intestinal dendritic cells (DCs). Tolerogenic (ovalbumin), immunogenic (F4 fimbriae, CT and CT-B) as well as the less immunogetic F18 fimbriae will be used as antigens and the pathogenic F4+enterotoxigenic E.coli, F18+verotoxigenic E.coli as well as the non-pathogenic E. coli HB101 and Lactococcus Lactis. A genomic wide approach with the pig microarray of Affymetrix will be used to study the early responses and dual photon-microscopy to study the passage of antigens/microorganisms through the epithelial barrier and their uptake by DCs.