Research Explorer

Project

In vitro generation of AML specific T cells from gematopoietic stem cells and functional characterization of these cells in an in vivo animal model
Code
3G064310
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Hematology
    • Immunology
    • Laboratory medicine
    • Hematology
    • Immunology
    • Laboratory medicine
Keywords
cell therapy T cells stem cells
 
Project description

Hematopoietic stem cells will be transduced to express a T Cell Receptor. This receptor will be optained by immunizing against WT1 tumor antigen. The T cell receptor genes will be cloned from WT1 speciific T cells and subsequently used for transduction of the stem cells. Stem cells will be differentiated in vitro to T cells and functionality will be assayed in an in vivo animal model.