Looking back into the future: ancestral reconstruction as a strategy for enzyme engineering

01 October 2013 → 30 September 2017
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Catalysis and reacting systems engineering
    • Chemical product design and formulation
    • General chemical and biochemical engineering
    • Process engineering
    • Separation and membrane technologies
    • Transport phenomena
    • Other (bio)chemical engineering
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
biocatalysis enzyme engineering ancestral reconstruction
Project description

Recent studies have shown that present-day enzymes often do not display enough plasticity to allow significant engineering of their substrate preference. Therefore, one of their progenitors will be used here as starting point for the creation of new specificities. Such an ancestral sequence should behave like a pluripotent stem cell that is able to adopt a variety of specialized functions.