Code
01D27213
Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Proteins
-
Engineering and technology
- Biomaterials
Keywords
biocatalysis
enzyme engineering
ancestral reconstruction
Project description
Recent studies have shown that present-day enzymes often do not display enough plasticity to allow significant engineering of their substrate preference. Therefore, one of their progenitors will be used here as starting point for the creation of new specificities. Such an ancestral sequence should behave like a pluripotent stem cell that is able to adopt a variety of specialized functions.