Project

Entry process of porcine arterivirus in macrophages and link with virulence/pathogenicity

Duration
01 March 2015 → 28 February 2017
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
pathogenicity entry arterivirus monocytes
 
Project description

Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus in pigs that has a specific tropism for monocytic cells. The last two decennia, the virus is genetically changing, resulting in the infection of more and more subsets of monocytic
cells.
This causes higher virus replication and more disease. In the present project the basis
of the monocyte switch will be examined.