A common theme emerges in host-pathogen interactions at the intestinal surface in humans and animals. Many gut pathogens or their toxins bind to receptors carrying blood group antigens present in the apical membrane of gut epithelial cells. We have shown previously that a molecule mimicking these receptors prevents binding of F18-fimbriated E. coli to the gut epithelium in piglets and protect these animals against infection with these pathogens. Here, we aim to investigate whether this molecule can also prevent binding of other gut pathogens that use blood group antigens as a receptor to interact with the gut epithelium in pigs and humans.