Code
01G02320
Duration
01 January 2020 → 31 October 2026
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Genetic predisposition
Keywords
Inherited retinal disease
genomics
transcriptomics
proteomics
interaction profiling
splicing
cis-regulation
iPSC
photoreceptor precursor cell
CRISPR/Cas9 editing
Xenopus tropicalis
antisense
oligonucleotide treatment
Project description
This multidisciplinary project aims (1) to decipher cis-regulation in human retina by chromatin conformation profiling, and by the study of regulatory elements in a human and animal model;; (2) to design an integrative framework for omics data analysis to explain missing heritability in inherited
blindness;; (3) to design and test antisense oligonucleotide-based treatments of novel targets, ultimately resulting in precision medicine for inherited blindness.