Code
01G02320
Looptijd
01-01-2020 → 31-10-2026
Financiering
Regional and community funding: Special Research Fund
Promotor
Onderzoeksdisciplines
-
Natural sciences
- Genetic predisposition
Trefwoorden
Erfelijke blindheid
genomica
transcriptomica
proteomica
interactie profilering
splicing
cis-regulatie
iPSC
fotoreceptor precursor cel
CRISPR/Cas9 modificatie
Xenopus tropicalis
antisense oligonucleotide behandeling
Projectomschrijving
This multidisciplinary project aims (1) to decipher cis-regulation in human retina by chromatin conformation profiling, and by the study of regulatory elements in a human and animal model;; (2) to design an integrative framework for omics data analysis to explain missing heritability in inherited
blindness;; (3) to design and test antisense oligonucleotide-based treatments of novel targets, ultimately resulting in precision medicine for inherited blindness.