Research Explorer

Project

Macrocyclic lactones as an additional measure for malaria parasite and vector control in Ethiopia
Code
01W00119
Duration
01 October 2019 → 31 July 2024
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Epidemiology
  • Agricultural and food sciences
    • Veterinary public health and food safety
Keywords
pharmacokinetics pharmacodynamics Macrocyclic lactones malaria burden control
 
Project description
 

Current malaria control measures have led to a change in vector comportment which brings a new challenge to target outdoor malaria transmission. Comparative efficacy and pharmacokinetic studies of different macrocyclic lactones (MLs) will be done in local cattle breeds targeting the vector
mosquitoes. Next, the MLs will be evaluated and compared regarding their sporontocidal and gametocytocidal effect on the malaria parasite.