Project

Integrated study of intracavitary drug delivery for the treatment of peritoneal carcinomatosis

Code

01J07211

Duration

01 July 2011 → 01 September 2017

Funding

Regional and community funding: Special Research Fund

Promotor

Wim Ceelen

Research disciplines

Medical and health sciences
- Morphological sciences
- Oncology
- Physiology
- Morphological sciences
- Oncology
- Physiology
- Morphological sciences
- Oncology
- Physiology

Keywords

intraperitoneal hipec chemotherapy

Project description

This project aims to study in a colorectal xenograft model the effects of anti-VEGF and anti-PDGFR therapy on the efficacy of intraperitoneal (IP) chemoperfusion with cisplatin and oxaliplatin. Specifically, we will study the effects of combined therapy on 1. the tumor microenvironment (IFP and tissue oxygenation); 2. pharmacokinetic and pharmacodynamic properties; and 3. antineoplastic properties (tumor growth delay, TGD).