Project

Dissecting the role of secretion systems in virulence of Burkholderia cenocepacia, the causative of cepacia syndrome in cystic fibrosis patients

Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Microbiology
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Microbiology
Keywords
cystic fibrosis proteomics bacterial infections
 
Project description

Burkholderia cenocepacia is an opportunistic pathogen that may cause severe complications for cystic fibrosis patients. We aim to apply proteomic technology to identify proteins that are secreted by the type III en IV secretion systems and consequently injected in the host cell. We will study the influence of environmental conditions on the levels of virulence factors and determine their effect on the viability of the host cell and on its immune response. Our basic research is meant to evaluate the potential of secretion systems as future antibiotic targets.