Unraveling the 17q enigma in neuroblastoma: from functional genomics to molecular therapy

01 October 2008 → 30 September 2012
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Molecular and cell biology
    • Molecular and cell biology
human genetics cancer pediatrics
Project description

Neuroblastoma is a pediatric tumor of the peripheral nervous system. In this study we aim to investigate the role of 17q gain in the oncogenesis of this tumour through (1) the study of integrated genomics of NB, medulloblastoma, tumour initiating cells and normal precursor cells, (2) functional identification of oncogenic 17q miRNAs, (3) analysis of the NB 17q mutome and (4) analysis of chromosome 17 candidate NB genes.