Duration
01 August 2014 → 30 September 2020
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Natural sciences
- Scientific computing
- Bioinformatics and computational biology
-
Medical and health sciences
- Bioinformatics and computational biology
- Laboratory medicine
- Palliative care and end-of-life care
- Regenerative medicine
- Tropical medicine
- Other basic sciences
- Bioinformatics and computational biology
- Laboratory medicine
- Palliative care and end-of-life care
- Regenerative medicine
- Tropical medicine
- Other clinical sciences
- Public health care
- Public health services
- Other health sciences
- Nursing
- Other paramedical sciences
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Bioinformatics and computational biology
- Laboratory medicine
- Palliative care and end-of-life care
- Regenerative medicine
- Tropical medicine
- Other translational sciences
- Other medical and health sciences
-
Engineering and technology
- Chemical product design and formulation
- Biomaterials engineering
- Scientific computing
Keywords
antimalaria
biorelevant dissolution
pharmaceutical quality
IVIVR
neglected diseases
anthelmintics
tablets
substandard medicines
Project description
Functional in-vitro dissolution systems for selected antimalaria and anthelmintic medicines will be developed using biorelevant media and hydrodynamics to dissolve the active drug from the tablet, coupled to caco-2 and parasites to quantify the diffusion permeability. A global IVIV model will be developed, and verified by in-vivo pharmacokinetics.
