Code
01J04207
Duration
01 January 2007 → 31 October 2009
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Medical and health sciences
- Dermatology
- Dermatology
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Dermatology
-
Engineering and technology
- Biomaterials engineering
- Biological system engineering
- Biomaterials engineering
- Biomechanical engineering
- Other (bio)medical engineering
- Environmental engineering and biotechnology
- Industrial biotechnology
- Other biotechnology, bio-engineering and biosystem engineering
Keywords
siRNA
hyperpigmentation
non-viral carriers
Project description
In this project siRNA molecules, directed against MyoVa exon F isoforms, will be complexed with different non-viral carriers. A physicochemical characterization of these siRNA carrier complexes will be conducted. In addition, a biological evaluation (effect of silencing, toxicity, depth of penetration through the different layers of the skin) of these siRNA carrier complexes will be performed in in vitro cultured primary melanocytes, an ex vivo skin model and finally in vivo in mice.