Project

Evaluation of the therapeutic possiblities of siRNA in the treatment of hyperpigmentation of the skin

Code

01J04207

Duration

01 January 2007 → 31 October 2009

Funding

Regional and community funding: Special Research Fund

Promotor

Jo Lambert

Research disciplines

Medical and health sciences
- Dermatology
- Dermatology
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Dermatology
Engineering and technology
- Biomaterials engineering
- Biological system engineering
- Biomaterials engineering
- Biomechanical engineering
- Other (bio)medical engineering
- Environmental engineering and biotechnology
- Industrial biotechnology
- Other biotechnology, bio-engineering and biosystem engineering

Keywords

siRNA hyperpigmentation non-viral carriers

Project description

In this project siRNA molecules, directed against MyoVa exon F isoforms, will be complexed with different non-viral carriers. A physicochemical characterization of these siRNA carrier complexes will be conducted. In addition, a biological evaluation (effect of silencing, toxicity, depth of penetration through the different layers of the skin) of these siRNA carrier complexes will be performed in in vitro cultured primary melanocytes, an ex vivo skin model and finally in vivo in mice.