The concept of socio-ecological metabolism offers a compelling framework to explore the evolving relationships between humans and nature, particularly in geographically distinct areas like the Scheldt estuary, which connects Antwerp, Ghent, and their surrounding regions. This approach enables both global historical analysis and close examination of local dynamics. In the 19th century, economic growth, industrialization, and urbanization in these key cities profoundly altered the human-nature balance. The exponential rise in resource extraction and consumption, alongside the increased output of waste, pollution, and fossil fuels, triggered severe environmental challenges, including degradation, biodiversity loss, and climate change. The digitization of historical maps, permits, statistical records, and early scientific observations for this specific region provides unprecedented insights into these complex human-environment interactions in a global perspective. Additionally, the project aims to develop and critically assess digital methods for geospatial research in the humanities.