The goal of ENCCA is to estabilish a durable, integrated clinical and translationaa research infrastructure in Europe for optimization of the management of cancer in children and adolescents. ENCCA aims to bring togheter the existing informal chlinical trial groups towards a European virtual Institute to reduce knowledge fragmentation and to enhance communication and collaboration. Our main contribution in this project is the integration and harmonization of existing biologial datasets and experimental data to enable targeted herapy.