Project

Alphaherpesviruses and the innate antiviral defence in the respiratory and genital tract: a fight for supremacy

Duration
01 January 2017 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
animal alphaherpesviruses (pseudorabies virus, bovine herpesvirus 1) herpes simplex virus type 1 & 2 innate immunity
 
Project description

Alphaherpesvirus infections cause respiratory and genital problems in humans and animals. In the present project proposal, it will be examined how alphaherpesviruses cross different barriers of the respiratory and genital mucosa (mucus, defensins, basement membrane) and how they escape local innate immunity (interferon, ILC/NK cells). The research results will contribute to the development of new/better drugs and vaccines.