DIFFER stands for ‘Diagonal Interventions to Fast-Forward Enhanced Reproductive health’ and aims at improving access to sexual and reproductive health (SRH) for the most vulnerable by a better linkage between interventions targeted at most-at-risk populations, in particular female sex workers, and the general reproductive health services. It will be implemented at four sites in Kenya (Mombasa), Mozambique (Tete), South Africa (Durban) and India (Mysore). The project has a strong south-south component and will translate previous successes and lessons learned in India to the Sub-Saharan African context.