Project

Controlled delivery of connexin43 mimetic peptide by nanocontainers for therapy of systemic inflammation

Code
01IO3618
Duration
01 October 2018 → 31 July 2023
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology not elsewhere classified
    • Laboratory medicine not elsewhere classified
    • Palliative care and end-of-life care
    • Regenerative medicine not elsewhere classified
    • Other basic sciences not elsewhere classified
    • Immunogenetics
    • Clinical microbiology
    • Palliative care and end-of-life care not elsewhere classified
    • Cell therapy
    • Other clinical sciences not elsewhere classified
    • Other health sciences not elsewhere classified
    • Pediatric nursing
    • Other paramedical sciences not elsewhere classified
    • Innate immunity
    • Laboratory medicine not elsewhere classified
    • Cell therapy
    • Other translational sciences not elsewhere classified
  • Engineering and technology
    • Ceramic and glass materials not elsewhere classified
    • Materials science and engineering not elsewhere classified
    • Nanomaterials
    • Other materials engineering not elswhere classified
Keywords
systemic inflammation connexin mimetic peptide delivery systems nanocontainers polymers TNF
 
Project description

Acute systemic inflammation is often associated with many severe life- threatening diseases. We found that connexin43 mimetic peptides are effective when applied prophylactically, while they lose their effectiveness when injected after the onset of systemic inflammation. We aim to develop nanocontainers capable of high loading of connexin43 peptides and their sustained release to ameliorate the signs of systemic inflammation.