Code
01IO3618
Duration
01 October 2018 → 31 July 2023
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Medical and health sciences
- Immunology not elsewhere classified
- Laboratory medicine not elsewhere classified
- Palliative care and end-of-life care
- Regenerative medicine not elsewhere classified
- Other basic sciences not elsewhere classified
- Immunogenetics
- Clinical microbiology
- Palliative care and end-of-life care not elsewhere classified
- Cell therapy
- Other clinical sciences not elsewhere classified
- Other health sciences not elsewhere classified
- Paediatric nursing
- Other paramedical sciences not elsewhere classified
- Innate immunity
- Laboratory medicine not elsewhere classified
- Cell therapy
- Other translational sciences not elsewhere classified
-
Engineering and technology
- Ceramic and glass materials not elsewhere classified
- Materials science and engineering not elsewhere classified
- Nanomaterials
- Other materials engineering not elswhere classified
Keywords
systemic inflammation
connexin mimetic peptide
delivery systems
nanocontainers
polymers
TNF
Project description
Acute systemic inflammation is often associated with many severe life- threatening diseases. We found that connexin43 mimetic peptides are effective when applied prophylactically, while they lose their effectiveness when injected after the onset of systemic inflammation. We aim to develop nanocontainers capable of high loading of connexin43 peptides and their sustained release to ameliorate the signs of systemic inflammation.