In-situ characterization of drug release and dissolution processes in sustained-release solid dosage forms

01 October 2018 → 30 September 2022
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Image processing
  • Medical and health sciences
    • Other paramedical sciences not elsewhere classified
    • In vitro testing
    • Pharmaceutical technology
  • Engineering and technology
    • Destructive and non-destructive testing of materials
    • Other (bio)medical engineering not elsewhere classified
    • Data visualisation and imaging
micro-CT X-ray imaging pharmaceutical technology sustained release material characterization in-situ measurements
Project description

In this project, the drug release process of sustained-release dosage forms will be in-situ monitored by dynamic visualization based on 4D-μCT. To achieve this, new developments in dynamic highresolution X-ray tomography (4D-μCT) will be made for both image acquisition and processing. This knowledge gained will enable to optimize drug formulations and their manufacturing process.