Project

Messenger RNA transfected myeoloid-derived suppressor cells as cellular vehicles for tumor-targeted delivery of IL-12

Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Immunology
    • Morphological sciences
    • Oncology
Keywords
cancer gene therapy cell migration
 
Project description

This research focuses on the use of cellular vehicles for the delivery of therapeutic agents. These carriers are used as Trojan horses to deposit nucleic acid constructs that code for anti-cancer agents in the vicinity of a tumor. Additionally, the constructs possess regulatory elements which allow external regulation of the production of these agents. In brief, this model aims to provide researchers and clinicians a tool to specifically target malignant regions of interest without the need for high systemic concentrations and their associated adverse effects.