Towards a targeted therapy for diabetic neuropathy: a cross-sectional study and exercise training intervention to improve pathophysiological understanding.

01 October 2023 → 30 September 2027
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Rehabilitation sciences
    • Pathophysiology
    • Systems physiology
muscle fiber type peripheral neuropathy protein metabolism Diabetes type 2
Project description

Approximately 50% of all patients with type 2 diabetes mellitus (T2DM) develop diabetic neuropathy (DNP), which leads to a decrease in muscle mass and strength. This sarcopenic effect can theoretically be attributed to a shift in muscle fiber type and a negative protein turnover, resulting from reduced mitochondrial function and inflammation. There are some studies that report a shift to a more anaerobic type IIx fibers in the case of T2DM, but these results are derived from people with or without DNP (undefined). Therefore, a first aim of this project is to investigate the impact of DNP on muscle fiber composition and protein turnover. Additionally, a recent study reported that exercise can reverse the negative impact on muscle strength, without elucidating the mechanism. Therefore, a second aim of this project is to investigate the impact of combined aerobic and strength training on these outcomes.