Research Explorer

Project

The mechanism of alphaherpesvirus US3-mediated activation of p21-activated kinases (PAKs) and its consequences on nuclear egress and viral spread.
Code
3E014510
Duration
01 October 2010 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
Keywords
activated kinase p21 US3 herpesvirus
 
Project description
 

PAKs play a crucial role in pseudorabies virus US3 kinase-induced cytoskeletal rearrangements and also seem to be involved in nuclear egress. In this research project, the mechanism and biological consequences of US3-PAK activation will be unravelled. The interaction between US3 and PAKs and their role in viral spread and in the nucleus will be studied in detail.