Code
3E014510
Duration
01 October 2010 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Natural sciences
- Microbiology
- Systems biology
-
Medical and health sciences
- Laboratory medicine
- Microbiology
- Laboratory medicine
- Laboratory medicine
- Microbiology
Keywords
activated kinase
p21
US3
herpesvirus
Project description
PAKs play a crucial role in pseudorabies virus US3 kinase-induced cytoskeletal rearrangements and also seem to be involved in nuclear egress. In this research project, the mechanism and biological consequences of US3-PAK activation will be unravelled. The interaction between US3 and PAKs and their role in viral spread and in the nucleus will be studied in detail.