Project

Profound study of the function of several matrix metalloproteinases (MMPs) in innate immunity, amongst others against bacterial infections

Duration
01 October 2008 → 01 October 2009
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Microbiology
    • Immunology
Keywords
bacterial infections sepsis matrix metalloproteinases (MMPs)
 
Project description

LPS injection in mammalians induces a septic-like response. BB-94 (a MMP inhibitor) and also MMP7 and MMP8 knockouts have shown to protect mice against LPS. Subsequently, the aim of this projects is to study the therapeutic niches of (new development) MMP inhibitors and to have a closer look to the role of MMPs in different immunological models.