Research Explorer

Project

Role of protein crystals in asthma?
Code
01GB2817
Duration
01 January 2017 → 31 October 2022
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Condensed matter physics and nanophysics
    • Medicinal and biomolecular chemistry
    • Biochemistry and metabolism
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Immunology
    • Medical biochemistry and metabolism
    • Molecular and cell biology
    • Respiratory medicine
    • Biophysics
    • Immunology
    • Medical biochemistry and metabolism
    • Molecular and cell biology
    • Respiratory medicine
    • Biophysics
    • Immunology
    • Medical biochemistry and metabolism
    • Molecular and cell biology
    • Respiratory medicine
Keywords
epithelial cells asthma eosinophils
 
Project description
 

Since 1853 it is known that Charcot Leyden crystals are found in asthmatic airways, and here we propose they promote allergy. We combine immunology with structural biology to investigate the structure, function and evolutionary origins of these and related protein crystals. Through novel tool creation and multidisciplinary research, we envisage the unmasking of a novel drugable pathway in asthma.