Regio- and stereoselective ring expansions of 2-(2-cyanoethyl)aziridines toward functionalized pyrrolidines and piperidines

01 October 2013 → 25 December 2017
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
ring transformations stereochemistry pyrrolidines aziridines regiochemistry piperidines
Project description

2-(2-Cyanoethyl)aziridines will be deployed for the construction of novel 2-(aminomethyl)pyrrolidines and 3-aminopiperidines via LiAlH4-induced transformations. Special attention will be devoted to the control of the regio- and stereochemistry. This project aims at providing new fundamental insights in the field of aziridine chemistry. In addition, selected target compounds will be evaluated in terms of their potential bioactivity (antimalarial agents).