Research Explorer

Project

Development of innovative approaches based on quorum sensing inhibition to prevent and treat medical device-related infections
Code
3E008511
Duration
01 October 2011 → 31 December 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
Keywords
quorum sensing medical devices biomaterials biofilm bacterial infections
 
Project description
 

Biofilm-associated microorganisms are resistant to antibiotics, causing problems for the treatment of biofilm-related infections. Bacterial cell-cell communication (quorum sensing, QS) may contribute to biofilm resistance. The goal is to develop biomaterials loaded with QS inhibitors and to evaluate their effect on microbial adhesion and/or antibiotic susceptibility. Besides this, combination therapy will be evaluated in chronic wound and respiratory tract infections.