Project

Preclinical assessment of the therapeutic potential of multitargeting cancer stem cells through modulation of the unfolded protein response and deubiquitinases in hepatocellular carcinoma.

Duration
01 October 2016 → 30 September 2020
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Systems biology
    • Other biological sciences
  • Medical and health sciences
    • Laboratory medicine
    • Morphological sciences
    • Oncology
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Laboratory medicine
    • Morphological sciences
    • Oncology
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Laboratory medicine
    • Morphological sciences
    • Oncology
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
Hepatocellular carcinoma (HCC) endoplasmic reticulum (ER)
 
Project description

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. The limited beneficial effects of current treatments make effective therapy a crucial unmet medical need. We aim at unravelling the interconnection of the unfolded protein response (UPR), deubiquitinases (DUBs) and stemness in the pathogenesis of HCC to provide clinically relevant tools for the treatment of this deadly disease.