Terrestrial biodiversity and ecosystems are being challenged by global changes, and threats to agricultural and forestry ecosystems represent some of the most serious environmental and socio-economic menaces that the planet and humanity are facing. Climate change (CG) is widely recognised as one of the most impactful global changes, and since it goes hand-by-hand with biodiversity and services loss in terrestrial ecosystems, they should be tackled together. Microbes constitute the life support system of the biosphere, but they are its most overlooked fraction and are not considered in the context of CG. The overall understanding of the impact of CG on the assembly and functions of microbiomes is still very limited. How the complex microbes-plants-soil interactions and its consequences on plant performance and productivity are impacted by CG is still largely unknown. Additional knowledge also needs to be obtained on the overall ecosystem functioning, and to what extent microbiomes may mitigate stress conditions due to CG. The project MICROBES-4-CLIMATE will provide a wider community of users/researchers, irrespective of location, efficient access to a cluster of complementary world-class Research Infrastructures and their integrated, advanced services along with training and scientific and/or technical support, to address such need. An excellence-driven programme of Transnational Access, which is at the core of the project, will enable users to conduct curiosity-driven research addressing terrestrial biodiversity and ecosystems, in light of the abovementioned multidimensional and still poorly understood microbiomes-plants-soil-environment interactions, and its roles in CG responses, resilience, and mitigation. This will foster the advancement of frontier knowledge and also pave the way to applied research on harnessing plant-microbiome interactions to improve the climate resiliency of plants/crops and to enable e.g., precision, sustainable and resilient agriculture.