Research Explorer

Project

Combining experimental and computational approaches to investigate arrhythmogenic consequences of connexin hemichannel opening in the heart.

Code
3F008015
Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biophysics
    • Cardiac and vascular medicine
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Physiology
    • Regenerative medicine
    • Other basic sciences
    • Biophysics
    • Cardiac and vascular medicine
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Physiology
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Biophysics
    • Cardiac and vascular medicine
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Physiology
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
  • Engineering and technology
    • Computer hardware
    • Computer theory
    • Scientific computing
    • Other computer engineering, information technology and mathematical engineering
Keywords
cardiology cellular electrophysiology connexin hemichannels system biology arrhythmia
 
Project description
 

Ventricular fibrillation is one of the leading causes of death in the industrialized world. Unfortunately, mechanistic insights in arrhythmia generation, maintenance and termination are still limited. To that purpose, we will perform an experimental-computational approach to explore the involvement of Cx43 hemichannels in cardiac excitability and arrhythmogenesis and to determine their role as a potential target for therapeutic intervention to treat cardiac arrhythmia and disease.