HIV has become a chronic infection without disease progression under lifelong tretament with antiretroviral therapies. 

However, people living with HIV do experience more comorbidities at a younger age and increased aging. This seems to be mostly related to immunological alterations related to activation and exhaustion. 

Similar observations can be made for other chronic infectious diseases, such as EBV and CMV and/or chronic inflammatory-non infectious conditions eg IBD. 

By combining advanced clinical care (PRO questionnaire, follow-up and multidisciplinary care paths), with multiplex protein analysis, immunophenotyping and pathway discovery we aim to contribute in knowledge regarding biological processes that are shared between these conditions but also differentiate them from eachother, in order to identify pathophysiological targets and outcome predictors with the overall aim to increase QoL and treatment in people with chronic immune-mediated conditions.